Sirolimus protective effects on bone: the need to be demonstrated

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Sirolimus protective effects on bone: the need to be demonstrated.

Sir, We read with great interest the article by Ralf Westenfeld et al. [1] regarding the reduced serum levels of bone resorption markers (TRAP-5b and sRANKL) in patients treated with sirolimus (SRL) after renal transplantation compared to a calcineurin inhibitor (CI)-based regimen, and in vitro, SRL reduced osteoclast differentiation and osteoclast precursor proliferation. So the authors conclu...

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ژورنال

عنوان ژورنال: Nephrology Dialysis Transplantation

سال: 2012

ISSN: 0931-0509,1460-2385

DOI: 10.1093/ndt/gfr803